{Reference Type}: Journal Article
{Title}: FKBP Ligands-Where We Are and Where to Go?
{Author}: Kolos JM;Voll AM;Bauder M;Hausch F;
{Journal}: Front Pharmacol
{Volume}: 9
{Issue}: 0
{Year}: 2018
{Factor}: 5.988
{DOI}: 10.3389/fphar.2018.01425
{Abstract}: In recent years, many members of the FK506-binding protein (FKBP) family were increasingly linked to various diseases. The binding domain of FKBPs differs only in a few amino acid residues, but their biological roles are versatile. High-affinity ligands with selectivity between close homologs are scarce. This review will give an overview of the most prominent ligands developed for FKBPs and highlight a perspective for future developments. More precisely, human FKBPs and correlated diseases will be discussed as well as microbial FKBPs in the context of anti-bacterial and anti-fungal therapeutics. The last section gives insights into high-affinity ligands as chemical tools and dimerizers.