{Reference Type}: Comparative Study
{Title}: Thickness changes in the corneal epithelium and Bowman's layer after overnight wear of silicone hydrogel contact lenses.
{Author}: Lu F;Tao A;Tao W;Zhuang X;Shen M;
{Journal}: BMC Ophthalmol
{Volume}: 18
{Issue}: 1
{Year}: Nov 2018 3
{Factor}: 2.086
{DOI}: 10.1186/s12886-018-0956-2
{Abstract}: <B>BACKGROUND: </B>To investigate thickness changes in the corneal epithelium and Bowman's layer after overnight silicone hydrogel contact lens (CL) wear by using ultra-high resolution optical coherence tomography (UHROCT).<BR><B>METHODS: </B>Eleven subjects without CL wearing history were recruited for this study. An UHROCT was used to measure the thickness of the epithelium (ET), Bowman's layer (BT), stroma (ST), and total cornea (CCT) at the center of both eyes. A silicone hydrogel CL was inserted in the right eye of each subject, and the fellow non-CL wearing left eye served as the control. The lens was inserted at 9:30 pm and removed at 8:00 am the next morning. The subjects were evaluated at 9:00 pm (baseline), 9:30 pm (lens insertion), 10:00 pm (before sleep), 7:00 am (waking), 7:30 am, and 8:00 am (lens removal).<BR><B>RESULTS: </B>Compared to the lens insertion level, the ET of the lens-wearing eye increased by 5.73% at eye opening (P = 0.001). The ET of the non-CL wearing eye and the BT in both eyes did not change after overnight CL wear. Compared to baseline, the CCT of the lens-wearing eye increased by 2.87% upon waking (P = 0.003) and recovered 30 min later (P = 0.555). In contrast, compared to baseline, the CCT of the non-CL wearing eye did not increase upon waking (P = 0.105).<BR><B>CONCLUSIONS: </B>By using UHROCT, we found that overnight CL wear induced different swelling responses in the various sublayers of the cornea.<BR><B>BACKGROUND: </B>Retrospectively registered. Registration number: ChiCTR1800015115 . Registered 07 March 2018.