{Reference Type}: Journal Article
{Title}: Cobalt-Catalyzed Enantioselective Synthesis of Chiral gem-Bis(boryl)alkanes.
{Author}: Teo WJ;Ge S;
{Journal}: Angew Chem Int Ed Engl
{Volume}: 57
{Issue}: 39
{Year}: 09 2018 24
{Factor}: 16.823
{DOI}: 10.1002/anie.201805705
{Abstract}: We report an asymmetric synthesis of enantioenriched gem-bis(boryl)alkanes in an enantioselective diborylation of 1,1-disubstituted alkenes catalyzed by Co(acac)2 /(R)-DM-segphos. A range of activated and unactivated alkenes underwent this asymmetric diborylation in the presence of cyclooctene as a hydrogen acceptor, affording the corresponding gem-bis(boryl)alkanes with high enantioselectivity. The synthetic utility of these chiral organoboronate compounds was demonstrated through several stereospecific derivatizations and the synthesis of sesquiterpene and sesquiterpenoid natural products.