{Reference Type}: Journal Article
{Title}: Total laryngectomy: Surgical morbidity and outcomes - A case series.
{Author}: Pantvaidya GH;Raina S;Mondal A;Deshmukh A;Nair D;Pai P;Chaturvedi P;D'Cruz A;
{Journal}: Indian J Cancer
{Volume}: 54
{Issue}: 4
{Year}: Oct-Dec 2017
{Factor}: 1.397
{DOI}: 10.4103/ijc.IJC_463_17
{Abstract}: <B>BACKGROUND: </B>Total laryngectomy (TL) is a well-established procedure for laryngeal and hypopharyngeal cancers. There is an increasing number of TLs done after organ preservation strategies.<BR><B>OBJECTIVE: </B>The aim of this study was to report 30-day morbidity and survival outcomes in patients undergoing TL at a tertiary referral center.<BR><B>METHODS: </B>This was a retrospective review of a prospective database of TL patients operated during 2012-2013.<BR><B>METHODS: </B>Patient demographics and other data were captured from the database. Surgical complications were graded as per Clavien-Dindo grading system and were also divided into major and minor as per predecided criteria. Recurrence and survival data were computed using Kaplan-Meier survival curves.<BR><B>RESULTS: </B>A total of 169 patients underwent TL during the study period. About 34% of the patients had received prior radiation therapy. Around 18% of the patients had major complications with a pharyngocutaneous fistula rate of 22.4%. Ninety percent of these were managed conservatively. Though used in a small subset, microvascular reconstruction had the least complication rates. The 3-year disease-free survival and overall survival were 66% and 72%, respectively. There was no difference in survival between per primum and salvage surgery cohorts.<BR><B>CONCLUSIONS: </B>TL is a safe and oncologically sound procedure in patients with laryngeal and hypopharyngeal cancers. A large proportion of patients still undergo TL as a de novo procedure. This denotes that patients still present with locally advanced cancers which are not amenable to organ preservation.