{Reference Type}: Journal Article
{Title}: Analysis of miRNA expression profiling identifies miR-214-3p as a novel biomarker in sinonasal inverted papilloma.
{Author}: Teng Y;Li Y;Lin Z;Gao Y;Cao X;Lou X;Lin F;Li Y;
{Journal}: Epigenomics
{Volume}: 10
{Issue}: 12
{Year}: Dec 2018
{Factor}: 4.357
{DOI}: 10.2217/epi-2018-0071
{Abstract}: <B>OBJECTIVE: </B>To analyze the expression profile, diagnostic and clinicopathological significances of miRNAs in sinonasal inverted papilloma (SNIP).<BR><B>METHODS: </B>The expression profile of miRNAs was analyzed using a miRNA microarray approach. The potential functions and clinical significances of specific miRNAs were further analyzed by bioinformatics and statistical methods.<BR><B>RESULTS: </B>The microarray assay identified 37 significantly upregulated and 21 downregulated miRNAs in SNIP. Of nine miRNAs randomly selected, the expression levels of seven miRNAs were confirmed by quantitative real-time PCR. The potential target genes of several candidate miRNAs were enriched in some biological processes and cellular signaling pathways related to tumorigenesis. Receiever operating characteristic curve analysis for miR-214-3p indicated an area under the curve of 0.932. Notably, its expression level was significantly decreased in SNIP tissues and associated with SNIP staging and recurrence.<BR><B>CONCLUSIONS: </B>MiR-214-3p can possibly serve as a valuable biomarker and a therapeutic target for SNIP.