{Reference Type}: Journal Article
{Title}: Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review.
{Author}: Turnaturi R;Montenegro L;Marrazzo A;Parenti R;Pasquinucci L;Parenti C;
{Journal}: Eur J Med Chem
{Volume}: 155
{Issue}: 0
{Year}: Jul 2018 15
{Factor}: 7.088
{DOI}: 10.1016/j.ejmech.2018.06.017
{Abstract}: Despite the fact that the benzomorphan skeleton has mainly been employed in medicinal chemistry for the development of opioid analgesics, it is a versatile structure. Its stereochemistry, as well as opportune modifications at the phenolic hydroxyl group and at the basic nitrogen, play a pivotal role addressing the benzomorphan-based compounds to a specific target. In this review, we describe the structure activity-relationships (SARs) of benzomorphan-based compounds acting at sigma 1 receptor (σ1R), sigma 2 receptor (σ2R), voltage-dependent sodium channel, N-Methyl-d-Aspartate (NMDA) receptor-channel complex and other targets. Collectively, the SARs data have highlighted that the benzomorphan nucleus could be regarded as a useful template for the synthesis of drug candidates for different targets.