{Reference Type}: Journal Article
{Title}: Selenium-Based Nanozyme as Biomimetic Antioxidant Machinery.
{Author}: Huang Y;Liu Z;Liu C;Zhang Y;Ren J;Qu X;
{Journal}: Chemistry
{Volume}: 24
{Issue}: 40
{Year}: Jul 2018 17
{Factor}: 5.02
{DOI}: 10.1002/chem.201801725
{Abstract}: A self-assembly nanocomposite was designed to mimic intracellular enzymatic and non-enzymatic antioxidants-constituted antioxidant defense machinery. In this work, selenium nanocomponent served as one model to mimic antioxidant enzyme, whereas polydopamine was able to mimic non-enzymatic antioxidant biomolecule in living systems. With the excellent glutathione peroxidase-mimic capacity of selenium and the reducibility of polydopamine, this Se@pDA nanozyme could achieve synergetic antioxidative efficiency to protect cellular components against oxidative damage. The pneumonia model of mice further proved the potential of our nanocomposites for anti-inflammation therapy.