{Reference Type}: Journal Article
{Title}: Guidelines for prophylaxis of Pneumocystis pneumonia cannot rely solely on CD4-cell count in autoimmune and inflammatory diseases.
{Author}: Baulier G;Issa N;Gabriel F;Accoceberry I;Camou F;Duffau P;
{Journal}: Clin Exp Rheumatol
{Volume}: 36
{Issue}: 3
{Year}: May-Jun 2018
{Factor}: 4.862
{DOI}: 
{Abstract}: <B>OBJECTIVE: </B>Guidelines for preventing Pneumocystis pneumonia (PCP) in HIV patients are based on CD4 below 200/mm3. Such cut-off value is suggested to guide prophylaxis in non-HIV conditions (NHIV) especially in autoimmune and inflammatory diseases (AD). We aimed to determine if CD4 could be used to guide PCP prophylaxis in AD.<BR><B>METHODS: </B>CD4 and lymphocyte-count were retrospectively studied in patients diagnosed with PCP between January 2013 and February 2016.<BR><B>RESULTS: </B>129 patients were included. The median CD4-count was 302/mm3 in AD, which was significantly higher than in HIV patients (19/mm3; p<0.0001). Fifty percent (n=10) of AD patients had CD4 counts greater than 300/mm3.<BR><B>CONCLUSIONS: </B>Prophylaxis for PCP cannot rely solely on CD4-count in NHIV patients especially in AD.