{Reference Type}: Journal Article
{Title}: Gastric Cancer Cells in Peritoneal Lavage Fluid: A Systematic Review Comparing Cytological with Molecular Detection for Diagnosis of Peritoneal Metastases and Prediction of Peritoneal Recurrences.
{Author}: Virgilio E;Giarnieri E;Giovagnoli MR;Montagnini M;Proietti A;D'Urso R;Mercantini P;Valabrega S;Balducci G;Cavallini M;
{Journal}: Anticancer Res
{Volume}: 38
{Issue}: 3
{Year}: 03 2018
{Factor}: 2.435
{DOI}: 10.21873/anticanres.12347
{Abstract}: Detecting free tumor cells in the peritoneal lavage fluid of gastric cancer patients permits to assess a more accurate prognosis, predict peritoneal recurrence and select cases for a more aggressive treatment. Currently, cytology and molecular biology comprise the two most popular methods of detection that are under constant study by researchers.<BR>We burrowed into the available literature comparing cytological with molecular detection of free intraperitoneal gastric cancer cells. PubMed, Science Direct, Scopus and Google Scholar were the search engines investigated.<BR>As of 2017, 51 dedicated studies have been published. Messenger RNA of carcinoembryonic antigen was the genetic target most frequently described. The genetic technique is usually superior to cytology in sensitivity (38-100% vs. 12.3-67% respectively), whereas cytological examination tends to show a slight pre-eminence in specificity (approximately 100%).<BR>So far, given the imperfection of each method, employment of both cytology and molecular examination seem to be mandatory.