{Reference Type}: Journal Article
{Title}: Ionic liquid-enabled synthesis, cholinesterase inhibitory activity, and molecular docking study of highly functionalized tetrasubstituted pyrrolidines.
{Author}: Kumar RS;Almansour AI;Arumugam N;Althomili DMQ;Altaf M;Basiri A;D K;Sai Manohar T;S V;
{Journal}: Bioorg Chem
{Volume}: 77
{Issue}: 0
{Year}: 04 2018
{Factor}: 5.307
{DOI}: 10.1016/j.bioorg.2018.01.019
{Abstract}: A small library of novel spiropyrrolidine heterocyclic hybrids has been prepared regioselectively in 1-butyl-3-methylimidazoliumbromide ([bmim]Br) with good to excellent yields using a [3+2] cycloaddition reaction. These synthesized compounds were evaluated as potential agents for treating Alzheimer's disease. Compound 4b showed the most potent activity, with an IC50 of 7.9 ± 0.25 µM against acetylcholinesterase (AChE). The inhibition mechanisms for the most active compounds on AChE and butyrylcholinesterase (BChE) receptors were elucidated using molecular docking simulations.