{Reference Type}: Journal Article
{Title}: [Clinical and radiological characteristics of pulmonary tuberculosis in tobacco smokers].
{Author}: Kombila UD;Mbaye FBR;Dia Kane Y;Ka W;Toure Badiane NO;
{Journal}: Rev Mal Respir
{Volume}: 35
{Issue}: 5
{Year}: May 2018
{Factor}: 0.714
{DOI}: 10.1016/j.rmr.2017.04.006
{Abstract}: <B>BACKGROUND: </B>Tobacco smoke alters lung defense mechanisms against infections and so increases the risk of mycobacterium tuberculosis infection.<BR><B>OBJECTIVE: </B>To determine the particular clinical features of tuberculosis in smokers and identify risk factors.<BR><B>METHODS: </B>We conducted a prospective, cross-sectional study over a period of nine months in Dakar, Senegal. The Chi-square test and multiple logistic regression were used to identify differences between smokers and non-smokers and to identify factors associated with clinical outcomes.<BR><B>RESULTS: </B>We included 165 patients with active pulmonary tuberculosis (59 smokers versus 106 never-smokers). The average age of smokers was 43.8±12.7 versus 32.1±13.1 years (P<0.0001). Smokers were overwhelmingly male (98.3% versus 1.8%, P<0.0001). The average delay to consultation was longer among smokers (90 days [30-120] versus 60 days [30-90] ; P<0.0001). In multivariate analysis, alcohol abuse, increasing age, male sex, and an unknown retroviral status were independent risk factors for pulmonary tuberculosis. Haemoptysis was observed more frequently in smokers (49.1% versus 31.1%, P=0.017). With regards to chest X-ray features, smokers presented with more advanced, bilateral and cavitating lung lesions.<BR><B>CONCLUSIONS: </B>Diagnostic delay and haemoptysis are important characteristics of the pulmonary tuberculosis in tobacco smokers.