{Reference Type}: Journal Article
{Title}: DNA damage in acute myeloid leukemia patients of Northern Mexico.
{Author}: Dávila-Rodríguez MI;Cortés-Gutiérrez EI;Hernández-Valdés R;Guzmán-Cortés K;De León-Cantú RE;Cerda-Flores RM;Báez-De la Fuente E;
{Journal}: Eur J Histochem
{Volume}: 61
{Issue}: 4
{Year}: Dec 2017 11
{Factor}: 1.966
{DOI}: 10.4081/ejh.2017.2851
{Abstract}: The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage detected in patients with newly diagnosed AML was similar to that observed for the controls; this might be explained by the stimulation of a repair pathway by the pathogenesis itself. These findings indicate that inhibiting the repair pathway could be proposed to enhance the efficacy of chemotherapy.