{Reference Type}: Journal Article
{Title}: Non-compliance with IDSA guidelines for patients presenting with methicillin-susceptible Staphylococcus aureus prosthetic joint infection is a risk factor for treatment failure.
{Author}: Bouaziz A;Uçkay I;Lustig S;Boibieux A;Lew D;Hoffmeyer P;Neyret P;Chidiac C;Ferry T;
{Journal}: Med Mal Infect
{Volume}: 48
{Issue}: 3
{Year}: May 2018
{Factor}: 5.965
{DOI}: 10.1016/j.medmal.2017.09.016
{Abstract}: <B>OBJECTIVE: </B>The long-term impact of treatment strategies proposed by the IDSA guidelines for patients presenting with methicillin-susceptible S. aureus (MSSA) prosthetic joint infection (PJI) is not well-known.<BR><B>METHODS: </B>Retrospective (2000-2010) cohort study including patients presenting with MSSA hip or knee PJI. A univariate Cox analysis was performed to determine if the non-compliance with IDSA surgical guidelines was a risk factor for treatment failure.<BR><B>RESULTS: </B>Eighty-nine patients with a mean follow-up of 2.8 years were included. Non-compliance with IDSA surgical guidelines was associated with treatment failure (hazard ratio 2.157; 95% CI [1.022-4.7]). The American Society of Anesthesiologists score, inadequate antimicrobial therapy, and a rifampicin-based regimen did not significantly influence patient outcome.<BR><B>CONCLUSIONS: </B>Based on the IDSA guidelines, if a patient presenting with MSSA PJI is not eligible for implant retention, complete implant removal is needed to limit treatment failure.