{Reference Type}: Journal Article
{Title}: Relationship of Cord Blood Immunoglobulin E and Maternal Immunoglobulin E with Birth Order and Maternal History of Allergy in Albanian Mother/Neonate Pairs.
{Author}: Latifi-Pupovci H;Lokaj-Berisha V;Lumezi B;
{Journal}: Open Access Maced J Med Sci
{Volume}: 5
{Issue}: 6
{Year}: Oct 2017 15
暂无{DOI}: 10.3889/oamjms.2017.150
{Abstract}: <B>BACKGROUND: </B>Previous studies reported that familial factors such as birth order and mothers atopy might influence cord blood levels and development of allergies.<BR><B>OBJECTIVE: </B>The aim of the study was to evaluate the relationship of cord blood IgE and maternal IgE with birth order and mothers history of allergy in Albanian mother/neonate pairs.<BR><B>METHODS: </B>Study population represented 291 mother-infant pairs. Mothers were interviewed with a questionnaire for personal history of allergy and pregnancy history whereas serum IgE levels were determined using sandwich IRMA assay.<BR><B>RESULTS: </B>The mean level of cIgE in neonates with detectable levels was 1.59 (n = 78). No significant difference in means of cIgE was found between first born and later born neonates (p = 0.232) and between neonates of mothers with a negative and positive history of allergy (p = 0.125). Also, no significant difference was found between means of mIgE by birth order, whereas there was a significant difference of mIgE between mothers with and without a history of allergy (p = 0.01). In a group of neonates with detectable cIgE levels, maternal IgE levels were moderately correlated with cIgE levels.<BR><B>CONCLUSIONS: </B>Cord blood IgE is not affected by birth order and mothers history of allergy, whereas mothers IgE are affected by the history of allergy but not by birth order.