{Reference Type}: Journal Article
{Title}: Synthesis of piperazine sulfonamide analogs as diabetic-II inhibitors and their molecular docking study.
{Author}: Taha M;Irshad M;Imran S;Chigurupati S;Selvaraj M;Rahim F;Ismail NH;Nawaz F;Khan KM;
{Journal}: Eur J Med Chem
{Volume}: 141
{Issue}: 0
{Year}: Dec 2017 1
{Factor}: 7.088
{DOI}: 10.1016/j.ejmech.2017.10.028
{Abstract}: Piperazine Sulfonamide analogs (1-19) have been synthesized, characterized by different spectroscopic techniques and evaluated for α-amylase Inhibition. Analogs 1-19 exhibited a varying degree of α-amylase inhibitory activity with IC50 values ranging in between 1.571 ± 0.05 to 3.98 ± 0.397 μM when compared with the standard acarbose (IC50 = 1.353 ± 0.232 μM). Compound 1, 2, 3 and 7 showed significant inhibitory effects with IC50 value 2.348 ± 0.444, 2.064 ± 0.04, 1.571 ± 0.05 and 2.118 ± 0.204 μM, respectively better than the rest of the series. Structure activity relationships were established. Molecular docking studies were performed to understand the binding interaction of the compounds.