{Reference Type}: Case Reports
{Title}: Improvement of telbivudine on renal function and massive proteinuria: A case report.
{Author}: Liu J;Yao N;Zhao Y;
{Journal}: J Viral Hepat
{Volume}: 24
{Issue}: 0
{Year}: 11 2017
{Factor}: 3.517
{DOI}: 10.1111/jvh.12789
{Abstract}: The quality of life and extended survival of patients with chronic hepatitis B (CHB), especially those with decompensated liver cirrhosis, has been improved markedly with nucleos(t)ide analogs treatment. In such conditions, the influence of hepatitis B virus (HBV) infection and antiviral agents on renal function becomes a consideration with long-term use and ageing. Membranous glomerulonephritis has been confirmed as the most common histological renal lesion. In this study, we reported a CHB patient with decompensated cirrhosis showing a significant improvement in massive proteinuria along with elevation of estimated glomerular filtration rate (eGFR) after 1 year treatment with telbivudine. However, a well-designed study should be performed to confirm the causal association, and the molecular mechanism needs further investigation.