{Reference Type}: Journal Article
{Title}: [Reduced zinc concentration in expressed prostatic secretion relates to the pain symptoms of types Ⅲ and Ⅳ prostatitis].
{Author}: Mo LJ;Chen X;Wang XM;Li GY;Zhang X;Huang S;Xie ZB;Mo ZN;
{Journal}: Zhonghua Nan Ke Xue
{Volume}: 22
{Issue}: 6
{Year}: Jun 2016
暂无{Abstract}: <B>UNASSIGNED: </B>To determine the zinc levels in the expressed prostatic secretion (EPS) of the patients with different types of chronic nonbacterial prostatitis, and explore the reference value of zinc concentration in EPS in the diagnosis and treatment of prostatitis.<BR><B>METHODS: </B>We collected EPS samples from 35 healthy men and 173 patients with chronic nonbacterial prostatitis, including 65 cases of type ⅢA, 69 cases of type ⅢB, and 39 cases of type Ⅳ, according to the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). We compared the zinc levels in the EPS samples among different groups and analyzed the correlations of zinc concentration with the NIH-CPSI scores, WBC count, pH value, and age of the subjects.<BR><B>RESULTS: </B>The participants were aged 17－65 (32.5±8.5) years. The zinc concentrations in the EPS were significantly lower in the ⅢA (［162.2±10.8］ μg/ml) and ⅢB (［171.2±12.0］ μg/ml) than in the Ⅳ (［234.6±17.9］ μg/ml) (P<0.05 ) and the control group (［259.5±14.6］ μg/ml) (P<0.05 ). The zinc level was correlated negatively with the NIH-CPSI pain score (r=－0.248, P<0.01), quality of life score (r=－0.232, P<0.01), severity score (r=－0.270, P<0.01), total NIH-CPSI score (r=－0.281, P<0.01), and the pH value in EPS (r=－0.208, P<0.01), but showed no correlation with the WBC count and age of the subjects.<BR><B>CONCLUSIONS: </B>The reduced zinc concentration in the EPS of the patients with chronic nonbacterial prostatitis may be associated with the pain symptoms of the disease, which suggests the potential reference value of measuring the zinc concentration in EPS in the diagnosis and treatment of prostatitis.<BR>目的：探讨前列腺按摩液（EPS）中锌离子浓度对Ⅲ型和Ⅳ型前列腺炎诊疗的意义和参考价值。方法：根据NIH前列腺炎分型标准，将入选的173例研究对象分为ⅢA型(n=65)、ⅢB型(n=69)、Ⅳ型(n=39)前列腺炎，并以35例门诊健康体检、无前列腺炎症状者为对照组，检测4组EPS中锌离子浓度，并分析其与慢性前列腺炎症状评分（CPSI），年龄，EPS中白细胞计数、pH值等指标的相关性。结果： ⅢA型及ⅢB型前列腺炎患者EPS中锌离子浓度［(162.2±10.8) 、(171.2±12.0) μg/ml］显著低于Ⅳ型及对照组［(234.6±17.9)、(259.5±14.6) μg/ml)，P均<0.05］。EPS中锌离子浓度与疼痛评分、生活质量（QOL）评分、症状严重评分以及CPSI总评分均呈显著负相关（r分别为－0.284、－0.232、－0.270、－0.281，P均<0.01），与排尿症状评分无相关。EPS中锌离子浓度与白细胞计数、年龄无明确相关，与pH值呈负相关（r=－0.208，P<0.01）。结论：Ⅲ型和Ⅳ型前列腺炎患者EPS中锌离子浓度低下可能与疼痛等前列腺炎相关症状有关，EPS中锌离子浓度检测对Ⅲ型和Ⅳ型前列腺炎的诊疗具有潜在参考价值。.