{Reference Type}: Journal Article
{Title}: Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study.
{Author}: Adachi Y;Nojima M;Mori M;Yamashita K;Yamano HO;Nakase H;Endo T;Wakai K;Sakata K;Tamakoshi A;
{Journal}: World J Gastroenterol
{Volume}: 23
{Issue}: 19
{Year}: May 2017 21
{Factor}: 5.374
{DOI}: 10.3748/wjg.v23.i19.3488
{Abstract}: <B>OBJECTIVE: </B>To assess the relationship between serum levels of insulin-like growth factor-1 (IGF1)/IGF-binding protein-3 (IGFBP3) and the risk of esophageal carcinoma.<BR><B>METHODS: </B>We assessed the relationship between the serum levels of these molecules and the risk of esophageal cancer in a prospective, nested case-control study of participants from the Japan Collaborative Cohort Study. A baseline survey was conducted from 1988 to 1990. Of the 110585 enrolled participants, 35% donated blood samples. Those who had been diagnosed with esophageal cancer were considered cases for nested case-control studies. A conditional logistic model was used to estimate odds ratios for the incidence of esophageal cancer associated with serum IGF1 and IGFBP3 levels.<BR><B>RESULTS: </B>Thirty-one cases and 86 controls were eligible for the present assessment. The molar ratio of IGF1/IGFBP3, which represents the free and active form of IGF1, was not correlated with the risk of esophageal carcinoma. A higher molar difference between IGFBP3 and IGF1, which estimates the free form of IGFBP3, was associated with a decreased risk of esophageal carcinoma (P = 0.0146), and people in the highest tertile had the lowest risk (OR = 0.107, 95%CI: 0.017-0.669). After adjustment for body mass index, tobacco use, and alcohol intake, the molar difference of IGFBP3-IGF1 was inversely correlated with the risk of esophageal carcinoma (P = 0.0150).<BR><B>CONCLUSIONS: </B>The free form of IGFBP3, which is estimated by this molar difference, may be inversely associated with esophageal cancer incidence.