{Reference Type}: Case Reports
{Title}: A case of Fanconi syndrome due to a deferasirox overdose and a trial of plasmapheresis.
{Author}: Shah L;Powell JL;Zaritsky JJ;
{Journal}: J Clin Pharm Ther
{Volume}: 42
{Issue}: 5
{Year}: Oct 2017
{Factor}: 2.145
{DOI}: 10.1111/jcpt.12553
{Abstract}: <B>OBJECTIVE: </B>Deferasirox has nephrotoxic effects in the context of chronic therapy. This case report illustrates proximal tubular dysfunction (Fanconi syndrome) due to an acute deferasirox overdose.<BR><B>METHODS: </B>In response, we trialled plasmapheresis to eliminate the drug. Deferasirox levels were obtained in the context of three rounds of plasmapheresis. Given the half-life model of decay, we concluded that plasmapheresis may not have been successful. The patient ultimately recovered normal tubular function after 2 months.<BR><B>CONCLUSIONS: </B>This report is the first to describe acute deferasirox-induced nephrotoxicity, and the application of plasmapheresis that, ultimately, did not change the typical time to recovery.