{Reference Type}: Case Reports
{Title}: Localized Juvenile Spongiotic Gingival Hyperplasia: Report of Two Cases.
{Author}: Kalogirou EM;Chatzidimitriou K;Tosios KI;Piperi EP;Sklavounou A;
{Journal}: J Clin Pediatr Dent
{Volume}: 41
{Issue}: 3
{Year}: 2017
{Factor}: 1.338
{DOI}: 10.17796/1053-4628-41.3.228
{Abstract}: <B>OBJECTIVE: </B>Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a painless gingival swelling that histologically exhibits hyperplasia of the non-keratinized stratified squamous epithelium, intercellular edema and spongiosis of the spinus layer, and exocytosis of inflammatory cells. LJSGH pathogenesis remains to be elucidated, while a possible origin from the gingival sulcus epithelium is nowadays proposed.<BR><B>METHODS: </B>We report two cases of LJSGH with immunohistochemical evaluation of cytokeratins (CKs) 18 and 19.<BR><B>RESULTS: </B>Both cases concerned 12-year-old boys, who presented with a well-circumscribed bright red pedunculated papillary swelling on the marginal gingiva of the left maxillary lateral incisor. With the provisional diagnosis of LJSGH, the lesions were excised under local anesthesia and histological examination supported the final diagnosis of LJSGH. In both cases, the lesional epithelium showed intense and mild positivity for CK19 and CK18, respectively, while the adjacent normal gingival epithelium expressed CK19, but not CK18, only in the basal cell layer. The postoperative course was uneventful in both patients and no recurrence has been reported.<BR><B>CONCLUSIONS: </B>LJSGH is a recently introduced entity that is worth attention in the clinical pediatric dentistry. Clinical and histological examination is required for the final diagnosis, while immunohistochemistry has shed light to LJSGH pathogenesis.