{Reference Type}: Case Reports
{Title}: The t(8;14)(q24.1;q32) and its variant translocations: A study of 34 cases.
{Author}: Angi M;Kamath V;Yuvarani S;Meena J;Sitaram U;Manipadam MT;Nair S;Ganapule A;Fouzia NA;Abraham A;Viswabandya A;Poonkuzhali B;George B;Mathews V;Srivastava A;Srivastava VM;
{Journal}: Hematol Oncol Stem Cell Ther
{Volume}: 10
{Issue}: 3
{Year}: Sep 2017
暂无{DOI}: 10.1016/j.hemonc.2017.03.002
{Abstract}: <B>BACKGROUND: </B>The t(8;14)(q24.1;q32) and its variants - the t(2;8)(p12;q24.1) and t(8;22)(q24.1;q11.2) are associated with B-cell neoplasia and result in MYC/immunoglobulin (IG) gene rearrangement.<BR><B>METHODS: </B>We correlated the cytogenetic, molecular and clinico-pathological findings of patients with 8q24 translocations seen in the Department of Haematology, Christian Medical College, Vellore, from January 2003 to December 2015.<BR><B>RESULTS: </B>There were 34 patients with 8q24 translocations (31, ALL and three myeloma). The t(8;14) was seen in 25 patients, t(8;22) in seven and t(2;8) in two. The salient findings were as follows: 85% males; 79% adults, median age 37 years; L3 morphology in 61%; mature B immunophenotype in 77%; extra-medullary disease in 41%; additional abnormalities in 28 (85%), notably, structural abnormalities of chromosome 1q (41%) and 13q (9%) and monosomy 13 (15%); complex karyotypes in 68%. There were two double-hit lymphoma/leukemia, one with a t(14;18)(q32;q21) and the other with a t(3;14)(q27;q11.2), associated with nodal high grade B cell lymphoma and dermal leukemic infiltrates respectively. Only 13 samples were processed for DNA PCR and all these samples were positive for MYC-IgH (c-gamma type) rearrangement. Only in one patient, in addition to c-gamma, c-alpha rearrangement was also detected.<BR><B>CONCLUSIONS: </B>The frequency (1.7%) and distribution of these translocations in our series and the association with 1q and 13q abnormalities is similar to the literature. Trisomies 7 and 12 were seen in less than 10% of our patients.