{Reference Type}: Journal Article
{Title}: Association between diabetes mellitus/hyperglycaemia and peri-implant diseases: Systematic review and meta-analysis.
{Author}: Monje A;Catena A;Borgnakke WS;
{Journal}: J Clin Periodontol
{Volume}: 44
{Issue}: 6
{Year}: Jun 2017
{Factor}: 7.478
{DOI}: 10.1111/jcpe.12724
{Abstract}: <B>OBJECTIVE: </B>This systematic review investigates whether hyperglycaemia/diabetes mellitus is associated with peri-implant diseases (peri-implant mucositis and peri-implantitis).<BR><B>METHODS: </B>Electronic and manual literature searching was conducted. An a priori case definition for peri-implantitis was used as an inclusion criterion to minimize risk of bias. The Newcastle-Ottawa Scale was used for quality assessment; random effect models were applied; and results were reported according to the PRISMA Statement.<BR><B>RESULTS: </B>Twelve studies were eligible for qualitative and seven of them for quantitative analyses. Meta-analyses detected the risk of peri-implantitis was about 50% higher in diabetes than in non-diabetes (RR = 1.46; 95% CI: 1.21-1.77 and OR = 1.89; 95% CI: 1.31-2.46; z = 5.98; p < .001). Importantly, among non-smokers, those with hyperglycaemia had 3.39-fold higher risk for peri-implantitis compared with normoglycaemia (95% CI: 1.06-10.81). Conversely, the association between diabetes and peri-implant mucositis was not statistically significant (RR = 0.92; 95% CI: 0.72-1.16 and OR = 1.06; 95% CI: 0.84-1.27; z = 1.06, p = .29).<BR><B>CONCLUSIONS: </B>Within its limits that demand great caution when interpreting its findings, this systematic review suggests that diabetes mellitus/hyperglycaemia is associated with greater risk of peri-implantitis, independently of smoking, but not with peri-implant mucositis.