{Reference Type}: Journal Article
{Title}: The medicinal plants in the control of tuberculosis: Laboratory study on medicinal plants from the Northern Area of Pakistan.
{Author}: Ullah S;Hussain S;Khan SN;Khurram M;Khan I;Khan MA;
{Journal}: Int J Mycobacteriol
{Volume}: 6
{Issue}: 1
{Year}: Jan-Mar 2017
暂无{DOI}: 10.4103/ijmy.ijmy_11_17
{Abstract}: Tuberculosis (TB) ranks as the second leading cause of deaths due to infectious diseases. Although global efforts have been made to control TB, still, this is a serious threat as Mycobacterium tuberculosis (MTB) produced resistance against both the first- and second-line drugs. The increasing incidence of multidrug-resistant, extremely drug resistant, and totally drug-resistant TB worldwide requires extra efforts to search for new anti-TB drugs.<BR>The present study evaluated the antimycobacterial activities of Citrullus colocynthis, Calotropis procera, Ricinus communis, Capparis decidua, and Fagonia cretica plants' extracts against rifampicin-sensitive (H37Rv) and rifampicin-resistant (TMC331) strains of MTB.<BR>Out of 44 extracts, 19 extracts were found active against H37Rv sensitive strain. Highest activities were observed in chloroform extract of C. colocynthis (leaves) and n-hexane extract of R. communis (seeds) with minimum inhibitory concentration values of 2.5 mg/ml each.<BR>Results show antimycobacterial potential in some of the fractions of studied plants that may be utilized further for isolation of active compounds and as a possible cure against TB.