{Reference Type}: Journal Article
{Title}: Developmental origin of postnatal cardiomyogenic progenitor cells.
{Author}: Liu YH;Lai LP;Huang SY;Lin YS;Wu SC;Chou CJ;Lin JL;
{Journal}: Future Sci OA
{Volume}: 2
{Issue}: 2
{Year}: Jun 2016
暂无{DOI}: 10.4155/fsoa-2016-0006
{Abstract}: <B>OBJECTIVE: </B>To trace the cell origin of the cells involved in postnatal cardiomyogenesis.<BR><B>METHODS: </B>Nkx2.5 enhancer-eGFP (Nkx2.5 enh-eGFP) mice were used to test the cardiomyogenic potential of Nkx2.5 enhancer-expressing cells. By analyzing Cre excision of activated Nkx2.5-eGFP+ cells from different lineage-Cre/Nkx2.5 enh-eGFP/ROSA26 reporter mice, we traced the developmental origin of Nkx2.5 enhancer-expressing cells.<BR><B>RESULTS: </B>Nkx2.5 enhancer-expressing cells could differentiate into striated cardiomyocytes both in vitro and in vivo. Nkx2.5-eGFP+ cells increased remarkably after experimental myocardial infarction (MI). The post-MI Nkx2.5-eGFP+ cells originated from the embryonic epicardial cells, not from the pre-existing cardiomyocytes, endothelial cells, cardiac neural crest cells or perinatal/postnatal epicardial cells.<BR><B>CONCLUSIONS: </B>Postnatal Nkx2.5 enhancer-expressing cells are cardiomyogenic progenitor cells and originate from embryonic epicardium-derived cells.