{Reference Type}: Journal Article
{Title}: [Immune Tolerance Mediated by TIM-3,LAG-3 and BTLA and Their Reversion in Hematological Malignancies-Review].
{Author}: Chen SH;Zha XF;Li YQ;
{Journal}: Zhongguo Shi Yan Xue Ye Xue Za Zhi
{Volume}: 24
{Issue}: 5
{Year}: Oct 2016
暂无{DOI}: 10.7534/j.issn.1009-2137.2016.05.056
{Abstract}: The main mechanism of tumor immune suppression is due to the T cell exhaustion which is mediated by abnormal expression of T-cell immunosuppressive receptors in immune cells. Blocking these molecules may restore partial or all functions of T cells. This article reviews the advance on the role of the newly discovered T cell immuno-suppressive receptors such as TIM-3, LAG-3 and BTLA, including their mediated T cell-immune tolerance and the study of targeted immunotherapy in hematological malignancies, so as to provide the new strategy for immune-targeted therapy for hematological malignancies.