{Reference Type}: Journal Article {Title}: Therapy resistant idiopathic scleredema: an underlying pathology not always present. {Author}: Kalfa M;Koçanaoğulları H;Zihni FY;Karabulut G;Emmungil H;İnal V; {Journal}: Eur J Rheumatol {Volume}: 2 {Issue}: 4 {Year}: Dec 2015 暂无{DOI}: 10.5152/eurjrheum.2015.0004 {Abstract}: Scleredema is a rare connective tissue disorder of unknown pathogenesis. Three types of scleredema have been described, based on its association with postinfection, monoclonal gammopathy and diabetes mellitus. We report herein a case of scleredema which the diagnosis didn't get specified. The patient was followed regularly for 13 years and did not respond to various combinations of immunosuppressants and psoralen plus ultraviolet A therapy. Treatment of scleredema is quite difficult and of limited success. At present, there is no proved treatment for this disease.