{Reference Type}: Journal Article
{Title}: Apelin-13 as a novel target for intervention in secondary injury after traumatic brain injury.
{Author}: Bao HJ;Qiu HY;Kuai JX;Song CJ;Wang SX;Wang CQ;Peng HB;Han WC;Wu YP;
{Journal}: Neural Regen Res
{Volume}: 11
{Issue}: 7
{Year}: Jul 2016
{Factor}: 6.058
{DOI}: 10.4103/1673-5374.187049
{Abstract}: The adipocytokine, apelin-13, is an abundantly expressed peptide in the nervous system. Apelin-13 protects the brain against ischemia/reperfusion injury and attenuates traumatic brain injury by suppressing autophagy. However, secondary apelin-13 effects on traumatic brain injury-induced neural cell death and blood-brain barrier integrity are still not clear. Here, we found that apelin-13 significantly decreases cerebral water content, mitigates blood-brain barrier destruction, reduces aquaporin-4 expression, diminishes caspase-3 and Bax expression in the cerebral cortex and hippocampus, and reduces apoptosis. These results show that apelin-13 attenuates secondary injury after traumatic brain injury and exerts a neuroprotective effect.