{Reference Type}: Journal Article
{Title}: Parallels between single cell migration and barrier formation: The case of RhoB and Rac1 trafficking.
{Author}: García-Weber D;Millán J;
{Journal}: Small GTPases
{Volume}: 9
{Issue}: 4
{Year}: 07 2018 4
暂无{DOI}: 10.1080/21541248.2016.1231655
{Abstract}: The appearance of multicellularity implied the adaptation of signaling networks required for unicellular life to new functions arising in this remarkable evolutionary transition. A hallmark of multicellular organisms is the formation of cellular barriers that compartmentalize spaces and functions. Here we discuss recent findings concerning the role of RhoB in the negative control of Rac1 trafficking from endosomes to the cell border, in order to induce membrane extensions to restore endothelial barrier function after acute contraction. This role closely resembles that proposed for RhoB in controlling single cell migration through Rac1, which has also been observed in cancer cell invasion. We highlight these similarities as a signaling paradigm that shows that endothelial barrier integrity is controlled not only by the formation of cell-cell junctions, but also by a balance between ancestral mechanisms of cell spreading and contraction conserved from unicellular organisms and orchestrated by Rho GTPases.