{Reference Type}: Journal Article
{Title}: MiR-22 promotes porcine reproductive and respiratory syndrome virus replication by targeting the host factor HO-1.
{Author}: Xiao S;Du T;Wang X;Ni H;Yan Y;Li N;Zhang C;Zhang A;Gao J;Liu H;Pu F;Zhang G;Zhou EM;
{Journal}: Vet Microbiol
{Volume}: 192
{Issue}: 0
{Year}: Aug 2016 30
{Factor}: 3.246
{DOI}: 10.1016/j.vetmic.2016.07.026
{Abstract}: Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important viruses affecting the swine industry worldwide. MicroRNAs (miRNAs) play vital roles in virus-host interactions by regulating the expression of viral or host gene at posttranscriptional level. Our previous research showed that PRRSV infection down-regulates the expression of heme oxygenase-1 (HO-1), a pivotal cytoprotective enzyme, and overexpression of HO-1 inhibits PRRSV replication. In this study, we demonstrate that host miRNA miR-22 can downregulate HO-1 expression by directly targeting its 3' untranslated region. Suppression of HO-1 expression by miR-22 facilitates PRRSV replication. This work suggests that PRRSV may utilize cellular miRNA to modify antiviral host factor expression, enabling viral replication, which not only provides new insights into virus-host interactions during PRRSV infection, but also suggests potential therapies for PRRSV infection.