{Reference Type}: Journal Article
{Title}: The relationship between serum levels of vitamin D with asthma and its symptom severity: A case-control study.
{Author}: Nasiri Kalmarzi R;Zamani A;Fathallahpour A;Ghaderi E;Rahehagh R;Kooti W;
{Journal}: Allergol Immunopathol (Madr)
{Volume}: 44
{Issue}: 6
{Year}: Nov 2016 0
{Factor}: 2.094
{DOI}: 10.1016/j.aller.2016.04.016
{Abstract}: <B>BACKGROUND: </B>Asthma is a heterogeneous disease characterised by chronic inflammatory airways, and is affected by several immunological factors. One of the most discussed and researched hypotheses is the relationship between vitamin D serum levels with asthma. This study aimed to investigate the relationship between vitamin D serum levels with asthma and pulmonary functions in children in Kurdistan province, Iran.<BR><B>METHODS: </B>In this case-control study, 120 children ranging from 6 to 18 years were referred in summer for investigation. Participants were divided into two groups: asthma group, N=60; and control group, N=60. After serum separation, samples were analysed using vitamin D ELISA kit. Additionally, pulmonary function test and serum IgE levels were measured in both groups. Data were analysed using Chi-square test and multiple regression analysis in SPSS15.<BR><B>RESULTS: </B>No difference was shown between the groups in terms of gender composition (male: 57.5; female: 42.5) (P>0.05). Average Vitamin D serum level in the case group (17.98±8.68) was less than in control group (22.35±6.26) (P<0.01). In addition, the difference of vitamin D deficiency in level of suboptimal between the asthma (17.77±6.41) and the control group (24.9±3.18) was statistically significant (P<0.0001). Positive correlation existed between vitamin D levels with FEV1, FVC, and FEV1/FVC. Multiple regression analysis showed a reverse relationship between vitamin D levels with IgE serum levels; this remained after adjustment for potential confounders (e.g. age, sex, BMI, FEV1, and FVC).<BR><B>CONCLUSIONS: </B>The results showed that serum levels of vitamin D in asthma patients were less than in healthy people, and also reduced lung function in these patients. So, the serum levels of vitamin D in asthma patients must be checked continuously.