{Reference Type}: Case Reports
{Title}: Adenosquamous carcinoma of the tongue: clinicopathologic study and review of the literature.
{Author}: Satomi T;Kohno M;Hasagawa O;Enomoto A;Abukawa H;Chikazu D;Yoshida M;Matsubayashi J;Nagao T;
{Journal}: Odontology
{Volume}: 105
{Issue}: 1
{Year}: Jan 2017
{Factor}: 2.885
{DOI}: 10.1007/s10266-016-0261-6
{Abstract}: Adenosquamous carcinoma (ASC) of the tongue is an uncommon malignant oral neoplasm with mixed glandular and squamous differentiation and a propensity for aggressive clinical behavior. Here, we report a rare case of ASC of the lateral border of the tongue in a 65-year-old Japanese man. The patient was treated by radical operation and remained well for 6 months before developing metastasis of the hilar and pretracheal lymph nodes. Subsequently, the patient was treated with combined chemotherapy (nedaplatin plus docetaxel and S-1 for two cycles, intravenously) and radiotherapy. Radiation therapy of metastatic lymph nodes was performed at a total dose of 60 Gy and was delivered in 2 Gy fractions 5 days/week. The patient is currently tumor free and is being followed up carefully. This article describes a rare case of ASC of the tongue and its conventional histologic, immunohistochemical, and electron microscopic findings, together with a review of the literature. The findings provide important information to better understand the possible clinical and therapeutic approaches for this uncommon tumor of the tongue.