{Reference Type}: Journal Article
{Title}: A meta-analysis of the diagnostic value of detecting K-ras mutation in pancreatic juice as a molecular marker for pancreatic cancer.
{Author}: Yang J;Li S;Li J;Wang F;Chen K;Zheng Y;Wang J;Lu W;Zhou Y;Yin Q;Zhang H;Guo C;
{Journal}: Pancreatology
{Volume}: 16
{Issue}: 4
{Year}: Jul-Aug 2016
{Factor}: 3.977
{DOI}: 10.1016/j.pan.2016.04.033
{Abstract}: BACKGROUND: K-ras codon 12 mutation is one of the earliest genetic changes in the development of pancreatic cancer (PC) and accurate detection of K-ras mutations is gaining increasing attention in the field of molecular diagnosis.
METHODS: Original research articles which evaluated the diagnostic accuracy of K-ras mutation detection in PC were selected. Data were presented as forest plots and summary receiver operating characteristic curve analysis was used to summarize the overall test performance.
RESULTS: We assessed 16 studies from 15 published articles. The pooled sensitivity and specificity were 59% (95%CI: 54%-64%) and 87% (95%CI: 84%-89%), respectively. The pooled positive likelihood ratio and negative likelihood ratio were 4.13 (95%CI: 2.73-6.25) and 0.42 (95%CI: 0.32-0.56), respectively, and the pooled diagnostic odds ratio was 13.66 (95% CI: 7.25-25.74).
CONCLUSIONS: Our results indicate that the analysis of K-ras mutations in pancreatic juice has a considerable diagnostic value in PC. Further studies with rigorous design, large sample size, and multi-regional co-operation are needed.