{Reference Type}: Case Reports
{Title}: Regression of Intracranial Meningioma during Treatment with α1-Adrenoceptor Blocker.
{Author}: Hoegestoel EA;Berg-Johnsen J;
{Journal}: J Neurol Surg Rep
{Volume}: 77
{Issue}: 1
{Year}: Mar 2016
暂无{DOI}: 10.1055/s-0035-1571204
{Abstract}: Background Regression of meningioma has been reported after hemorrhage or hormonal withdrawal. Here, we report a case of an incidentally diagnosed meningioma that regressed in association with α1-adrenoceptor antagonist. Case report A 59-year old male patient with an incidentally diagnosed lateral sphenoid wing meningioma was followed with serial magnetic resonance imaging. The tumor with a maximum diameter of 43 mm showed progressive regression, and after 3 years the size was reduced to 22% of the initial volume. During follow-up the patient was treated with an α1-adrenoceptor antagonist (tamsulosin) for benign prostatic hyperplasia. Possible mechanisms are discussed, including our main hypothesis of reduced mitogenic effects through phospholipase C-signal transduction. Conclusion This is the first report of regression of an incidentally diagnosed meningioma associated with α1-adrenoceptor antagonist treatment.