{Reference Type}: Journal Article
{Title}: [Appropriate prescription, adherence and safety of non-steroidal anti-inflammatory drugs].
{Author}: Sostres C;Lanas Á;
{Journal}: Med Clin (Barc)
{Volume}: 146
{Issue}: 6
{Year}: Mar 2016 18
{Factor}: 3.2
{DOI}: 10.1016/j.medcli.2015.09.022
{Abstract}: Non-steroidal anti-inflammatory drugs (NSAIDs) are the most numerous category of drugs sharing the same mechanism of action and therapeutic activities (anti-inflammatory, analgesic and anti-pyretic). Despite having similar efficacy for pain relieve, the different available NSAIDs show variability in its safety profile. The risk of gastrointestinal and cardiovascular complications varies depending on the dose of NSAID and also the presence of different risk factors. It is necessary, therefore, an individualized case assessment before establishing the indication of the best NSAID for each patient, taking account of the best gastroprotection strategy. Improved prescription and enhanced treatment adherence are central objectives to reduce NSAID-related complications. A recent consensus of the Spanish Association of Gastroenterology and the Spanish societies of Cardiology and Rheumatology intends to promote the rational use of NSAIDs according to new recent studies. This review provides additional aspects to facilitate the optimal decision-making process in the routine use of these drugs in clinical practice.