{Reference Type}: Journal Article
{Title}: 2-(Nitroaryl)benzothiazole and benzoxazole derivatives as fluorogenic substrates for the detection of nitroreductase activity in clinically important microorganisms.
{Author}: Cellier M;Gignoux A;James AL;Orenga S;Perry JD;Robinson SN;Stanforth SP;Turnbull G;
{Journal}: Bioorg Med Chem Lett
{Volume}: 25
{Issue}: 24
{Year}: Dec 2015 15
{Factor}: 2.94
{DOI}: 10.1016/j.bmcl.2015.10.099
{Abstract}: A series of carboxy-substituted 2-(nitroaryl)benzothiazole derivatives and carboxy-substituted 2-(nitroaryl)benzoxazole derivatives were prepared and evaluated as potential nitroreductase substrates for the purpose of detecting clinically important microorganisms. Several of the substrates produced highly fluorescent colonies with the majority of a panel of 10 Gram-negative bacteria and also with two of a panel of 8 Gram-positive bacteria.