{Reference Type}: Journal Article
{Title}: Discovery of a new class of antiviral compounds: camphor imine derivatives.
{Author}: Sokolova AS;Yarovaya OI;Shernyukov AV;Gatilov YV;Razumova YV;Zarubaev VV;Tretiak TS;Pokrovsky AG;Kiselev OI;Salakhutdinov NF;
{Journal}: Eur J Med Chem
{Volume}: 105
{Issue}: 0
{Year}: Nov 2015 13
{Factor}: 7.088
{DOI}: 10.1016/j.ejmech.2015.10.010
{Abstract}: A new class of compounds featuring a camphor moiety has been discovered that exhibits potent inhibitory activity against influenza A(H1N1)pdm09 and A(H5N1) viruses. The synthesized compounds were characterized by spectroscopic analysis; in addition the structures of compound 2 and 14 were elucidated by the X-ray diffraction technique. Structure-activity relationship studies have been conducted to identify the 1,7,7-trimethylbicyclo[2.2.1]heptanes2-ylidene group as the key functional group responsible for the observed antiviral activity. The most potent antiviral compound is imine 2 with therapeutic index more than 500.