{Reference Type}: Case Reports
{Title}: A case of donepezil-related torsades de pointes.
{Author}: Kitt J;Irons R;Al-Obaidi M;Missouris C;
{Journal}: BMJ Case Rep
{Volume}: 2015
{Issue}: 0
{Year}: Oct 2015 5
暂无{DOI}: 10.1136/bcr-2015-211900
{Abstract}: An 80-year-old woman with Alzheimer's dementia presented with diarrhoea, vomiting and worsening confusion following an increase in donepezil dose from 5 to 10 mg. The ECG revealed prolongation of QTc interval. Soon after admission, she became unresponsive with polymorphic ventricular tachycardia (VT). Cardiopulmonary resuscitation with a 200 J shock was successful in establishing cardiac output. Following the discontinuation of donepezil, the QTc interval normalised and no further arrhythmias were recorded. Treatment with anticholinesterase inhibitors may result in life-threatening VT. Vigilance is required for the identification of this condition in patients presenting with presyncope, syncope or seizures.