{Reference Type}: Journal Article
{Title}: Efficacy and Safety of Calcipotriol/Betamethasone Dipropionate Ointment for the Treatment of Trachyonychia: An Open-Label Study.
{Author}: Park JM;Cho HH;Kim WJ;Mun JH;Song M;Kim HS;Ko HC;Kim BS;Kim MB;
{Journal}: Ann Dermatol
{Volume}: 27
{Issue}: 4
{Year}: Aug 2015
{Factor}: 0.722
{DOI}: 10.5021/ad.2015.27.4.371
{Abstract}: <B>BACKGROUND: </B>Despite efforts to treat trachyonychia, there is no promising treatment modality.<BR><B>OBJECTIVE: </B>This study evaluated the efficacy and safety of calcipotriol plus betamethasone dipropionate ointment on trachyonychia.<BR><B>METHODS: </B>A total of 39 patients with 432 nails affected by trachyonychia were enrolled. All patients applied calcipotriol/betamethasone ointment once daily without occlusion for 6 months. Outcome measures were assessed by physician's global assessment (degree of roughness: 0, clear; 1, mild; 2, moderate; 3, marked; 4, severe) at all time points.<BR><B>RESULTS: </B>After 6 months of therapy, 98.6% (426/432) of nails showed significant clinical improvement; 4.2% were completely free from nail lesions. The mean physician global assessment score decreased significantly from 3.5 to 1.7 points (p< 0.05). No serious side effects were reported, except mild pruritus and erythema in 2 patients.<BR><B>CONCLUSIONS: </B>This is the first study to prospectively evaluate the efficacy and safety of calcipotriol/betamethasone ointment for the treatment of trachyonychia. The results indicate topical calcipotriol/betamethasone is an effective and safe treatment for symptom improvement of trachyonychia.