{Reference Type}: Journal Article
{Title}: A mini-review on Biginelli adducts with notable pharmacological properties.
{Author}: de Fátima Â;Braga TC;Neto Lda S;Terra BS;Oliveira BG;da Silva DL;Modolo LV;
{Journal}: J Adv Res
{Volume}: 6
{Issue}: 3
{Year}: May 2015
{Factor}: 12.822
{DOI}: 10.1016/j.jare.2014.10.006
{Abstract}: Since the disclosure of Biginelli reaction by the chemist Pietro Biginelli, functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) have emerged as prototypes for the design of compounds with a broad variety of biological activities. This mini-review describes over 100 Biginelli adducts demonstrated to be promising anticancer, inhibitors of calcium channel, anti-inflammatory, antimicrobial and antioxidant agents. Thus, this compilation presents the most notable in vitro and in vivo results for such fascinating class of organic compounds.