{Reference Type}: Case Reports
{Title}: Cell-free fetal DNA in the maternal circulation originates from the cytotrophoblast: proof from an unique case.
{Author}: Hochstenbach R;Nikkels PG;Elferink MG;Oudijk MA;van Oppen C;van Zon P;van Harssel J;Schuring-Blom H;Page-Christiaens GC;
{Journal}: Clin Case Rep
{Volume}: 3
{Issue}: 6
{Year}: Jun 2015
暂无{DOI}: 10.1002/ccr3.285
{Abstract}: Noninvasive prenatal testing (NIPT) and direct karyotyping of cytotrophoblast were normal for a male fetus, but cultured chorionic villus mesenchymal cells and umbilical cord fibroblasts showed nonmosaic trisomy 18. This observation provides direct evidence for the cytotrophoblastic origin of cell-free fetal DNA and yields a biological explanation for falsely reassuring NIPT results.