{Reference Type}: Journal Article
{Title}: The prognostic performance of the complement system in septic patients in emergency department: a cohort study.
{Author}: Zhao X;Chen YX;Li CS;
{Journal}: Biomark Med
{Volume}: 9
{Issue}: 7
{Year}: 2015
{Factor}: 2.498
{DOI}: 10.2217/bmm.15.32
{Abstract}: <B>OBJECTIVE: </B>To investigate the prognostic performance of complement components in septic patients, complement 3, membrane attack complex (MAC) and mannose-binding lectin were measured and compared among adult patients with sepsis, severe sepsis and septic shock, as well as between in-hospital nonsurvivors and survivors.<BR><B>METHODS: </B>The prognostic value of complement components was compared with mortality in emergency department sepsis (MEDS) score.<BR><B>RESULTS: </B>Median complement 3, MAC and mannose-binding lectin increased directly with the sepsis, severe sepsis and septic shock groups, and were significantly higher in nonsurvivors than in survivors.<BR><B>CONCLUSIONS: </B>MEDS and MAC independently predicted in-hospital mortality. The prognostic performance of MAC was superior to MEDS as analyzed by receiver operating characteristic curve and area under the curve.