{Reference Type}: Case Reports
{Title}: Association of Van Wyk Grumbach and Debre Semelaigne Syndromes with Severe Hypothyroidism.
{Author}: Oden Akman A;Tayfun M;Demirel F;Ucakturk SA;Gungor A;
{Journal}: J Pediatr Adolesc Gynecol
{Volume}: 28
{Issue}: 6
{Year}: Dec 2015
{Factor}: 2.046
{DOI}: 10.1016/j.jpag.2015.03.004
{Abstract}: <B>BACKGROUND: </B>Van Wyk Grumbach syndrome (VWGS) and Kocher-Debre Semelaigne syndrome (KDSS) are rare forms of pseudo-precocious puberty and myopathy in patients with longstanding untreated hypothyroidism. We present the case of an adolescent girl who developed pseudo-precocious puberty and myopathy caused by long-term untreated hypothyroidism.<BR><B>METHODS: </B>A 17-year-old female patient was referred to our outpatient clinic due to menstrual irregularities. She had muscle pain and multiple cystic ovaries in addition to clinical signs of severe congenital hypothyroidism. High levels of creatinine and creatinine kinase and accompanying muscle hypertrophy were present. After the initiation of L-thyroxine therapy, the symptoms were alleviated in a short time.<BR><B>CONCLUSIONS: </B>Congenital and acquired hypothyroidism should be considered in the differential diagnosis of pseudo-precocious puberty and myopathy that presents with muscle pain, muscle hypertrophy, and elevated creatinine kinase levels.