{Reference Type}: Journal Article
{Title}: Pediatric non-Hodgkin lymphomas: first report from Central Africa.
{Author}: Budiongo AN;Ngiyulu RM;Lebwaze BM;Gini-Ehungu JL;Mafuta EM;Ekulu PM;Kabongo-Mpolesha JM;Aloni MN;
{Journal}: Pediatr Hematol Oncol
{Volume}: 32
{Issue}: 4
{Year}: May 2015
{Factor}: 2.07
{DOI}: 10.3109/08880018.2015.1013231
{Abstract}: <B>BACKGROUND: </B>Information on presentation and outcome of pediatric non-Hodgkin's lymphoma is limited from Africa. The demographic characteristics, distribution of different subtypes were noted and compared with published reports from other parts of the world.<BR><B>METHODS: </B>The study was conducted in Kinshasa, the Democratic Republic of Congo between January 2002 and December 2012.<BR><B>RESULTS: </B>A total of 63 cases of pediatric non-Hodgkin's lymphoma were retrospectively analyzed. This cohort represents the largest series of pediatric non-Hodgkin's lymphoma presented from sub-Saharan Africa. Median age was 8.7±3.6 years. There were 43 (68.3%) males. A mean of 82 ± 59 days passed from detection of the first sign to referral to oncology unit. Morphology distribution showed that 42 cases (66.7%) had a diagnosis of Burkitt lymphoma, 16 cases (25.4%) had diffuse large B-cell lymphoma and 5 cases (7.9%) had NHL-not otherwise specified. The majority of patients (82.5%) had advanced stage (stage III and IV). Immunohistochemistry findings were available for 32 biopsy samples. All (100%) cases were B-cell non-Hodgkin's lymphoma and immunohistochemistry had identified 18 (56.3%) cases of Burkitt lymphoma. In our cohort, 22 of 32 cases expressed positive bcl-2 and 12 (37.5%) were found to be positive for bcl-6. Thirty-one (96.7%) cases were positive for high Ki-67 antigen expression. Assuming that cases lost to follow-up worsened and died, the mortality would be 98.4%.<BR><B>CONCLUSIONS: </B>In comparison to western data, we observed higher proportion of B-cell non-Hodgkin's lymphoma, Burkitt Lymphoma and patients with bcl-2 expression.