{Reference Type}: Journal Article
{Title}: Friedreich's ataxia--a case of aberrant transcription termination?
{Author}: Butler JS;Napierala M;
{Journal}: Transcription
{Volume}: 6
{Issue}: 2
{Year}: 2015
暂无{DOI}: 10.1080/21541264.2015.1026538
{Abstract}: Reduced expression of the mitochondrial protein Frataxin (FXN) is the underlying cause of Friedreich's ataxia. We propose a model of premature termination of FXN transcription induced by pathogenic expanded GAA repeats that links R-loop structures, antisense transcription, and heterochromatin formation as a novel mechanism of transcriptional repression in Friedreich's ataxia.