{Reference Type}: Journal Article
{Title}: DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status.
{Author}: Barbosa AS;de Oliveira LR;Tavares FC;de Lima CR;Diório SM;Calvi SA;Vilani-Moreno FR;Pereira PC;
{Journal}: J Venom Anim Toxins Incl Trop Dis
{Volume}: 21
{Issue}: 0
{Year}: 2015
暂无{DOI}: 10.1186/s40409-015-0006-y
{Abstract}: <B>BACKGROUND: </B>Jorge Lobo's disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.<BR><B>METHODS: </B>DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).<BR><B>RESULTS: </B>The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.<BR><B>CONCLUSIONS: </B>These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.