{Reference Type}: Clinical Trial
{Title}: Non-invasive fat reduction of the flanks using a new cryolipolysis applicator and overlapping, two-cycle treatments.
{Author}: Bernstein EF;Bloom JD;Basilavecchio LD;Plugis JM;
{Journal}: Lasers Surg Med
{Volume}: 46
{Issue}: 10
{Year}: Dec 2014
暂无{DOI}: 10.1002/lsm.22302
{Abstract}: <B>OBJECTIVE: </B>A sharply contoured cryolipolysis vacuum applicator was developed to improve fit and tissue draw in the abdomen and flanks to better accommodate a range of body types and a variety of treatment sites. This study was carried out to evaluate the safety and efficacy of the new applicator for treatment of flank fat ("love handles").<BR><B>METHODS: </B>A cryolipolysis vacuum applicator with a sharply contoured cup and curved cooling plates was used to treat 20 flanks. Two treatment cycles were delivered sequentially to each flank (60-minute cycle at a Cooling Intensity Factor of 41.6). Efficacy was evaluated 12 weeks post-treatment by physicians performing blinded, independent review of clinical photographs. Safety was assessed by the treating physician monitoring subjects for side effects and adverse events.<BR><B>RESULTS: </B>Four blinded, independent physician reviewers properly identified the pre- and post-treatment photographs 94.4% of the time. Improvement was scored from 0 (none) to 10 (complete) and showed an average 4.3 point (43%) improvement. Side-effects were limited to erythema, edema, bruising, and numbness or tingling at the treatment site, and resolved without treatment.<BR><B>CONCLUSIONS: </B>Multiple treatment cycles from a new improved-fit cryolipolysis applicator are safe and effective for reduction of flank fat bulges. A high degree of improvement was reported by blinded, physician evaluation of standardized photographs.