{Reference Type}: Journal Article
{Title}: Distinct factors bind the AP-1 consensus sites in gibbon ape leukemia virus and simian virus 40 enhancers.
{Author}: Quinn JP;Takimoto M;Iadarola M;Holbrook N;Levens D;
{Journal}: J Virol
{Volume}: 63
{Issue}: 4
{Year}: Apr 1989
{Factor}: 6.549
{DOI}: 10.1128/JVI.63.4.1737-1742.1989
{Abstract}: We have demonstrated that the gibbon ape leukemia virus (GALV) enhancer AP-1 element and the simian virus 40 AP-1 enhancer element bind different factors in HeLa nuclear extracts. A 39-kilodalton HeLa nuclear protein and the c-fos protein bind to the GALV element. Antibodies to c-fos abolish binding to the GALV AP-1 site. In contrast, anti-c-fos immunoglobulin fails to inhibit formation of the simian virus 40-specific complex from extracts of HeLa cells. Thus, AP-1-binding complexes are subject to compositional variation at different binding sites.