{Reference Type}: Case Reports
{Title}: [A case of micafungin-hyposensitive Candida glabrata due to FKS2 gene mutation].
{Author}: Inui S;Nakamura T;Tanabe K;Ohno H;Koike C;Okuda K;Nakata C;Fujimoto H;Ohkura H;Miyazaki Y;Takahashi H;
{Journal}: Kansenshogaku Zasshi
{Volume}: 88
{Issue}: 3
{Year}: May 2014
暂无{DOI}: 
{Abstract}: Candida glabrata was continuously isolated in cultured urine samples from a subject with thrombotic thrombocytopenic purpura. Yeast-like fungal phagocytosis found in gram staining led to agents being tested for antifungal susceptibility, revealing hyposensitivity to micafungin (MCFG) of MIC < 2 mg/mL. MCFG administered for 10 days failed to cure C. glabrata infection. To clarify why hyposensitivity occurred, we analyzed the FKS gene sequence using the PCR, finding a deficit of 3 bases coding phenylalanine at FKS2 gene amino acid 659. MCFG hyposensitivity may thus occur in long-term candin-class anti-fungal agent treatment. Candin-class agents have potent anti-fungal activity with fewer adverse effects and are widely used clinically. Hyposensitivity due to resistant C. glabrata species showed thus be considered in fungal infection treatment.