{Reference Type}: Journal Article {Title}: Five polyostotic conditions that general orthopedic surgeons should recognize (or should not miss). {Author}: Muthusamy S;Conway SA;Temple HT; {Journal}: Orthop Clin North Am {Volume}: 45 {Issue}: 3 {Year}: Jul 2014 {Factor}: 2.771 {DOI}: 10.1016/j.ocl.2014.04.004 {Abstract}: General orthopedic surgeons frequently encounter patients with conditions affecting multiple bones. It is important to recognize common polyostotic diseases. This article describes five polyostotic conditions: Multipe Enchondromatosis (Ollier Disease and Maffucci syndrome), Multiple Hereditary Exostosis (Diaphyseal Aclasis), Fibrous Dysplasia (McCune-Albright syndrome and Mazabraud syndrome), Paget's Disease of bone (Osteitis Deformans), and Skeletal Metastases. This is a survey of the clinical, pathologic and radiographic features that assist in diagnosing these conditions. Also, an overview of the laboratory findings, treatment, follow-up, and prognosis is presented. Recognizing these diseases will aid in prompt and accurate diagnosis and appropriate referral and therapy.