{Reference Type}: Case Reports
{Title}: Case report: stimulation of the right amygdala induces transient changes in affective bias.
{Author}: Bijanki KR;Kovach CK;McCormick LM;Kawasaki H;Dlouhy BJ;Feinstein J;Jones RD;Howard MA;
{Journal}: Brain Stimul
{Volume}: 7
{Issue}: 5
{Year}: Sep-Oct 2014
{Factor}: 9.184
{DOI}: 10.1016/j.brs.2014.05.005
{Abstract}: <B>BACKGROUND: </B>Sensitive outcome measures are needed to quantify the effects of neuromodulation in mood disorders.<BR><B>OBJECTIVE: </B>This study examined the utility of a novel affective bias (AB) task in identifying transient mood changes induced by amygdala stimulation in a single rare participant.<BR><B>METHODS: </B>Localized, pulsed electrical stimulation was delivered for 8 min during measures of AB and self-reported mood. Responses were compared with those gathered without stimulation on the same day in the same setting, using paired t-tests.<BR><B>RESULTS: </B>Stimulation of the basolateral nucleus of the right amygdala at 50 Hz, 15 V, and 200 μs pulse-width produced a significant positive shift in AB (t = -2.864, df = 53, P = .006), despite equivocal findings on self-reported mood (t = -.184, df = 12, P = .857).<BR><B>CONCLUSIONS: </B>Affective bias may be more sensitive to stimulation-induced fluctuations in mood than subjective report, suggesting utility as an outcome measure in neuromodulation studies.